Abstract 47: Delayed Tolerance Induction Protocol for Vascularized Composite Allografts in Non-Human Primates: The Immunomodulatory Effect of Donor Bone Marrow Transplantation Does Not Prevent the Development of Chronic Rejection in the Absence of Durable Mixed Chimerism
نویسندگان
چکیده
PURPOSE: Globally, 39 million people suffer from blindness. Whole eye transplantation (WET) offers the opportunity to provide a viable optical system to recipients with irreversible vision loss. We have previously established a viable orthotropic model for vascularized whole eye transplant in the rat. The purpose of our study is to evaluate gross morphology, structural integrity and aqueous humor dynamics in a long-term WET survivor, as well to evaluate for any adverse effects of WET in the unoperated, contralateral eye.
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